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1

KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

Koene, Saskia, Spaans, Edwin, Van Bortel, Luc, Van Lancker, Griet, Delafontaine, Brant, Badilini, Fabio, Beyrath, Julien, Smeitink, Jan

Journal:

Orphanet Journal of Rare Diseases

Year:

2017

Language:

english

File:

PDF, 741 KB

english, 2017

2

SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans

Krabbendam, Inge E., Honrath, Birgit, Dilberger, Benjamin, Iannetti, Eligio F., Branicky, Robyn S., Meyer, Tammo, Evers, Bernard, Dekker, Frank J., Koopman, Werner J. H., Beyrath, Julien, Bano, Daniel

Journal:

Cell Death and Disease

Year:

2020

File:

PDF, 5.54 MB

2020

3

Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway

Maria Vittoria Spanedda, Béatrice Heurtault, Steffen Weidner, Corinne Baehr, Emmanuelle Boeglin, Julien Beyrath, Sara Milosevic, Line Bourel-Bonnet, Sylvie Fournel, Benoît Frisch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 423 KB

english, 2010

4

Stabilisation indirecte interne par un feedback localement distribué de systèmes d'équations couplées

Journal:

Comptes Rendus de l'Académie des Sciences - Series I - Mathematics

Year:

2001

File:

PDF, 80 KB

2001

5

Antitumor activity of liposomal ErbB2/HER2 epitope peptide-based vaccine constructs incorporating TLR agonists and mannose receptor targeting

Jean-Sébastien Thomann, Béatrice Heurtault, Steffen Weidner, Mélanie Brayé, Julien Beyrath, Sylvie Fournel, Francis Schuber, Benoît Frisch

Journal:

Year:

2011

Language:

english

File:

PDF, 889 KB

english, 2011

6

Replacement of Ala by Aib improves structuration and biological stability in thymine-based α-nucleopeptides

Geotti-Bianchini, Piero, Moretto, Alessandro, Peggion, Cristina, Beyrath, Julien, Bianco, Alberto, Formaggio, Fernando

Journal:

Organic & Biomolecular Chemistry

Year:

2010

Language:

english

File:

PDF, 361 KB

english, 2010

7

Cysteine-rich Domain 1 of CD40 Mediates Receptor Self-assembly

Smulski, C. R., Beyrath, J., Decossas, M., Chekkat, N., Wolff, P., Estieu-Gionnet, K., Guichard, G., Speiser, D., Schneider, P., Fournel, S.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

8

Design and synthesis of intrinsically cell-penetrating nucleopeptides

Geotti-Bianchini, Piero, Beyrath, Julien, Chaloin, Olivier, Formaggio, Fernando, Bianco, Alberto

Journal:

Organic & Biomolecular Chemistry

Year:

2008

Language:

english

File:

PDF, 172 KB

english, 2008

9

Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions

Gorska, Katarzyna, Beyrath, Julien, Fournel, Sylvie, Guichard, Gilles, Winssinger, Nicolas

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 1.26 MB

english, 2010

10

Multivalent DR5 Peptides Activate the TRAIL Death Pathway and Exert Tumoricidal Activity

Pavet, V., Beyrath, J., Pardin, C., Morizot, A., Lechner, M.-C., Briand, J.-P., Wendland, M., Maison, W., Fournel, S., Micheau, O., Guichard, G., Gronemeyer, H.

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 847 KB

english, 2010

11

Toward high-content screening of mitochondrial morphology and membrane potential in living cells

Iannetti, Eligio F., Willems, Peter H.G.M., Pellegrini, Mina, Beyrath, Julien, Smeitink, Jan A.M., Blanchet, Lionel, Koopman, Werner J.H.

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2015

Language:

english

File:

PDF, 2.49 MB

english, 2015

12

Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics

Foriel, Sarah, Willems, Peter, Smeitink, Jan, Schenck, Annette, Beyrath, Julien

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2015

Language:

english

File:

PDF, 449 KB

english, 2015

13

A Simple Approach to Cancer Therapy Afforded by Multivalent Pseudopeptides That Target Cell-Surface Nucleoproteins

Destouches, D., Page, N., Hamma-Kourbali, Y., Machi, V., Chaloin, O., Frechault, S., Birmpas, C., Katsoris, P., Beyrath, J., Albanese, P., Maurer, M., Carpentier, G., Strub, J.-M., Van Dorsselaer, A.,

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

14

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

Schirris, Tom J.J., Renkema, G. Herma, Ritschel, Tina, Voermans, Nicol C., Bilos, Albert, van Engelen, Baziel G.M., Brandt, Ulrich, Koopman, Werner J.H., Beyrath, Julien D., Rodenburg, Richard J., Wil

Journal:

Cell Metabolism

Year:

2015

Language:

english

File:

PDF, 1.78 MB

english, 2015

15

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy

Iannetti, Eligio F, Smeitink, Jan A M, Beyrath, Julien, Willems, Peter H G M, Koopman, Werner J H

Journal:

Nature Protocols

Year:

2016

Language:

english

File:

PDF, 2.60 MB

english, 2016

16

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy

Iannetti, Eligio F., Smeitink, Jan A.M., Beyrath, Julien, Willems, Peter H.G.M., Koopman, Werner J.H.

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2016

Language:

english

File:

PDF, 106 KB

english, 2016

17

Mitochondrial disorders in children: toward development of small-molecule treatment strategies

Koopman, W. J., Beyrath, J., Fung, C.-W., Koene, S., Rodenburg, R. J., Willems, P. H., Smeitink, J. A.

Journal:

EMBO Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 721 KB

english, 2016

18

Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning

Blanchet, Lionel, Smeitink, Jan A. M., van Emst - de Vries, Sjenet E., Vogels, Caroline, Pellegrini, Mina, Jonckheere, An I., Rodenburg, Richard J. T., Buydens, Lutgarde M. C., Beyrath, Julien, Willem

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

19

Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling

Smulski, Cristian R, Decossas, Marion, Chekkat, Neila, Beyrath, Julien, Willen, Laure, Guichard, Gilles, Lorenzetti, Raquel, Rizzi, Marta, Eibel, Hermann, Schneider, Pascal, Fournel, Sylvie

Journal:

Cell Death and Disease

Year:

2017

Language:

english

File:

PDF, 3.23 MB

english, 2017

20

Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

de Haas, Ria, Das, Devashish, Garanto, Alejandro, Renkema, Herma G., Greupink, Rick, van den Broek, Petra, Pertijs, Jeanne, Collin, Rob W. J., Willems, Peter, Beyrath, Julien, Heerschap, Arend, Russel

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 6.94 MB

english, 2017

21

Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model

Foriel, Sarah, Beyrath, Julien, Eidhof, Ilse, Rodenburg, Richard J., Schenck, Annette, Smeitink, Jan A. M.

Journal:

Disease Models & Mechanisms

Year:

2018

Language:

english

File:

PDF, 7.59 MB

english, 2018

22

KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery

Beyrath, Julien, Pellegrini, Mina, Renkema, Herma, Houben, Lisanne, Pecheritsyna, Svetlana, van Zandvoort, Peter, van den Broek, Petra, Bekel, Akkiz, Eftekhari, Pierre, Smeitink, Jan A. M.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.84 MB

english, 2018

23

The KHENERGY study: Safety and efficacy of KH176 in mitochondrial m.3243A>G spectrum disorders

Janssen, Mirian CH, Koene, Saskia, de Laat, Paul, Hemelaar, Pleun, Pickkers, Peter, Spaans, Edwin, Beukema, Rypko, Beyrath, Julien, Groothuis, Jan, Verhaak, Chris, Smeitink, Jan

Journal:

Clinical Pharmacology & Therapeutics

Year:

2018

Language:

english

File:

PDF, 836 KB

english, 2018

24

Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD+

Iannetti, Eligio F., Smeitink, Jan A. M., Willems, Peter H. G. M., Beyrath, Julien, Koopman, Werner J. H.

Journal:

Cell Death and Disease

Year:

2018

Language:

english

File:

PDF, 2.10 MB

english, 2018

25

Exogenous NAD+ prevents galactose-induced death of Leigh Syndrome patient fibroblasts with isolated complex I deficiency

Koopman, Werner J.H., Iannetti, Eligio F., Smeitink, Jan A.M., Willems, Peter H.G.M., Beyrath, Julien

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year:

2018

Language:

english

File:

PDF, 80 KB

english, 2018

26

A Drosophila Mitochondrial Complex I Deficiency Phenotype Array

Foriel, Sarah, Renkema, G. Herma, Lasarzewski, Yvonne, Berkhout, Job, Rodenburg, Richard J., Smeitink, Jan A. M., Beyrath, Julien, Schenck, Annette

Journal:

Frontiers in Genetics

Year:

2019

Language:

english

File:

PDF, 1.19 MB

english, 2019

27

Indirect linear locally distributed damping of coupled systems

BEYRATH, Annick

Journal:

Boletim da Sociedade Paranaense de Matemática

Year:

2009

Language:

english

File:

PDF, 525 KB

english, 2009

28

Indirect linear locally distributed damping of coupled systems

BEYRATH, Annick

Journal:

Boletim da Sociedade Paranaense de Matemática

Year:

2009

File:

PDF, 525 KB

2009

29

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

Schwartzentruber, Aurelie, Boschian, Camilla, Lopes, Fernanda Martins, Myszczynska, Monika A., New, Elizabeth J., Beyrath, Julien, Smeitink, Jan, Ferraiuolo, Laura, Mortiboys, Heather

Journal:

Scientific Reports

Year:

2020

File:

PDF, 2.71 MB

2020